In fourth professional campaign, combined to go 4-7 with three saves and a 3.40 ERA (132.1 ip/50 er) in 39 appearances (19 starts) between Single-A Jupiter, Triple-A New Orleans and Miami. ..In eight starts with Marlins, went 2-3 with 4.06 ERA (44.1/20). In 10 relief outings, had no record and 3.86 ERA (14.0/6)...With New Orleans, had 2-3 mark with 2.83 ERA (47.2/15) in 10 starts, while going 0-1 with two saves and 3.63 ERA (22.1/9) in 10 appearances...Opened season on 10-day disabled list with a strained left oblique. Sent to NOLA upon reinstatement on April 11. Was recalled briefly on two occasions, from May 5-6 and May 17-19, before being recalled for remainder of season on July 28...Made five starts to open his season with NOLA, going 0-2, 4.15 before shifting to the bullpen for next seven appearances. Six of those seven relief outings were multiple innings, including two 3.0-inning outings...Returned to rotation on June 20 but bounced between there and 'pen for remainder of time in NOLA, making five starts and three relief outings in final eight appearances... Went 2-1, 2.08 (26.0/6) in final five starts for the Baby Cakes...Season debut in Miami was a spot-start on May 6 at Mets; took a loss after allowing eight runs (three earned) on five hits, four walks, and a hit batter, with four strikeouts, over 4.2 innings...In second stint with Miami, tossed 1.0 relief inning on May 18 at Dodgers (h, 2 r, 2 er, 4 bb)...Began third stint with Marlins in bullpen and made eight appearances (six scoreless) from July 30-August 23. In that time, posted 2.84 ERA (12.2 ip/4 er), with eight strikeouts to two walks...Also during that stretch, picked up first career save on Aug. 13 vs. Colorado...Seven of final eight appearances from Aug. 26 through end of season were starts. In those seven starts, went 2-2, 3.86 (39.2/17), allowing three-or-fewer runs six times, and two-or-fewer runs four times...Posted season high in innings pitched (7.0) in a loss vs. Washington on Sept. 5, despite allowing just one earned run. Equaled total in season finale, when he picked up a win vs. Atlanta on Sept. 30, allowing just two runs. Also in final start, struck out a season-best six batters...In final three starts of season, went 2-0, 3.32 (19.0/7). Earned first win as a Marlin on Sept. 25 at Colorado, the middle game of that stretch.
Split season between starting rotation (17 starts) and bullpen (37 appearances) with Baltimore, Triple-A Norfolk and Miami, going a combined 1- 11 with a 4.40 ERA (118.2 ip/58 er)...Opened season in starting rotation with Norfolk, making 12 starts prior to being recalled by Baltimore on June 14. Prior to recall, posted 1-6 record and 3.59 ERA (62.2/25)... Tossed season-best 6.2 scoreless innings in lone win of season, May 21 at Syracuse. Allowed eight hits without walking a batter and struck out seven... From May 16 to August 24, allowed more than one run just two times, while holding opponents scoreless four times. Owned 1.84 ERA (44.0/9) over nine-game stretch that included a scoreless 4.0 inning relief appearance on Aug. 24 vs. Rochester... Made first appearance of season with Baltimore on June 15 at Boston, tossing 2.2 scoreless frames... Surrendered two runs (one earned) in next appearance, June 19 vs. Toronto, before providing five consecutive scoreless outings (4.2 ip)... Was designated for assignment on September 5 and claimed off waivers by Miami on Sept. 15...Made three appearances out of bullpen with Miami, surrendering three runs in 3.0 innings.
Set career-highs in almost every category, including wins (five), losses (nine), games (34), games started (18), innings pitched (125.2 IP), and strikeouts (69) • Posted a 5-9 record with a 5.80 ERA (81 ER/125.2 IP) and 69 strikeouts and 32 walks while limiting the opposition to a .287 batting average in 34 games (18 starts) for the Padres • Made the first relief appearances of his career...Posted a 7.30 ERA (20 ER/24.2 IP) in 16 games out of the bullpen compared to a 5.44 ERA (61 ER/101.0 IP) as a starter • Began the season in the bullpen, making his first appearance of the season on 4/9 vs. SF in the third inning in relief of an injured Ian Kennedy and threw 4.2 perfect innings, the longest perfect outing by a reliever in team history and the longest by a Major League relief pitcher since Pittsburgh's Vin Mazzaro went 5.0 perfect frames on 6/30/13 vs. MIL • On two occasions, appeared in a single series as both a starter and a reliever: 4/20 (start) and 4/23 (relief) at COL and 9/11 (relief) and 9/13 (start) at SF...The last Padres pitcher to appear in two separate series in the same season as both a starter and a reliever was Andy Hawkins during the 1983 season...Hawkins started a game for the Padres on 6/24/83 at SF and entered the game in relief on 6/26 (GM1) and started a game on 8/30/83 at PHI (GM1) and entered the game the following day on 8/31 as a reliever • Prior to Despaigne, the last Major League pitcher to twice in one season make both a start and a relief appearance in a single series was Montreal's Sun Woo Kim during the 2004 season...Kim started the game on 6/28/04 at PHI and entered a game in relief on 7/1 and also entered a game in relief on 8/6 at HOU and started two days later on 8/8 • Posted a 17.0-inning scoreless streak from 5/21-31, a span of three appearances (two starts), the longest scoreless streak by a Padres pitcher in 2015
Signed with the Padres as a minor league free agent on 5/2, making his Major League debut with 16 starts after making seven starts between Double-A San Antonio and Triple-A El Paso...Made his Major League debut on 6/23 at SF, earning the win after working 7.0 shutout innings...Per STATS, Inc, was the seventh Major Leaguer since 1914 to pitch 7.0-or-more shutout innings and not allow a walk in his Big League debut...was the fourth pitcher in Padres franchise history to pitch 7.0-or-more shutout innings in his MLB debut, joining Ricky Bones on 8/11/91 (7.0 IP), Eric Nolte on 8/1/87 (7.0 IP) and Jimmy Jones on 9/21/86 (9.0 IP)...Became the second Cuban-born pitcher to ever appear in a game for the Padres (Eddie Oropesa, 16 games in 2004) and the first to ever make a start...His debut with starting catcher Yasmani Grandal was the first time since 6/13/69 that a Major League team started an all Cubanborn battery, per ELIAS…RHP Camilo Pascual and C Paul Casanova were the last such to do so for the Washington Senators...Over his 16 Major League starts total, went 4-7 with a 3.36 ERA (36 ER, 96.1 IP) and 65 strikeouts against 32 walks...Became the seventh player in Padres franchise history to earn a winning decision in each of his first two career appearances, joining Mike Thompson (2006), Oliver Perez (2002), Brian Tollberg in (2000), Joey Hamilton (1994), Larry Hardy (1974) and Dave Freisleben (1974)…the sixth starting pitcher in franchise history to do so...Over his eight starts at Petco Park, went 3-1 with a 1.83 ERA (11 ER, 54.0 IP) and 39 strikeouts against 16 walks while limiting opponents to a .188 average…with his first home start for the Padres on 6/29 vs. ARI, his home ERA in that time ranked sixth among qualifying National League starters (min. 45.0 IP)...Among NL rookies with as many-or-more innings (96.1), his 3.36 ERA and .237 opponents average ranked second-best...On 7/20 vs. NYM at Petco Park, tossed 7.2 innings of no-hit baseball before allowing a double to Daniel Murphy in the eighth, the longest no-hit bid by the Padres since Aaron Harang, Josh Spence, Chad Qualls and Mike Adams combined to throw 8.2 no-hit innings on 7/9/11 at LAD… was the longest individual no-hit effort for the Padres since Chris Young also went 7.2 no-hit innings 9/7/08 at MIL before Gabe Kapler homered with two-outs in the eighth inning...Began his career by working 6.0-or-more innings and allowing one run-or-less in his first three starts (6/23-7/5), the first starting pitcher in Padres history to do so and 11th Major Leaguer since 1914 to do so...Also began his career by working 6.0-or-more innings and allowing two earned runs-or-less in five of his first six starts, becoming the first pitcher in Padres history to do so and 16th National League pitcher since 1914 to do so.