Phegley attempted to slide around Perez, but was tagged out
The White Sox would score on a bases-loaded walk two batters later, extending their lead to 4-2.
Ventura is 17-for-36 in managerial challenges.
A 58-second crew chief review in the seventh confirmed a call on a fielder's choice that ruled Avisail Garcia out at the plate, not interfered by Perez by virtue of rule 7.13.
Daniel Kramer is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.