First base umpire Bill Miller ruled that Cuddyer was able to keep his foot on the bag and Pollock was out.
Pollock immediately jumped in the air and motioned for D-backs manager Kirk Gibson to come out and challenge the call.
A review ruled that the call would stand.
Mark Trumbo followed up the decision with a two-run homer to right that pulled the D-backs to within 6-2.
Steve Gilbert is a reporter for MLB.com. Read his blog, Inside the D-backs, and follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.