Facing an 0-2 count, with two outs in the third inning, Pujols fouled off four straight pitches before lining a low splitter over the head of Mariners third baseman Kyle Seager, giving the Angels a 3-0 lead. But the 34-year-old limped into second, grabbed his hamstring and was promptly removed from the game.
The unusually warm weather -- game-time temperature was 91 degrees -- likely contributed to the issue.
"I knew right away it was a cramp because as soon as I hit the bag I took about four or five steps, and that's when I felt it," said Pujols, who now has 1,595 career RBIs to tie Hall of Famer Mike Schmidt for 35th on the all-time list. "Obviously it's been really hot the last couple days."
Alden Gonzalez is a reporter for MLB.com. Read his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez. This story was not subject to the approval of Major League Baseball or its clubs.