Righty Phil Hughes takes the mound against left-handed Jose Quintana for Game 1 of Saturday's straight doubleheader, with a scheduled first pitch at 3:10 p.m. CT. Logan Darnell will take Milone's spot against rookie Scott Carroll in the nightcap. Trevor May will start Sunday's series finale as scheduled against Hector Noesi.
Milone is still seeking his first win for the Twins after arriving via a Trade Deadline deal for outfielder Sam Fuld.
In five starts with the Twins, Milone is 0-1 with a 7.94 ERA. He was 6-3 with a 3.55 ERA in 16 starts with the A's before the trade. Milone was relieved after 3 2/3 innings due to the tired pitching arm on Sept. 2, also against the White Sox.
The White Sox postponed the game just before 3 p.m. Friday with a 90 percent chance of rain expected through the evening to coincide with temperatures in the low-50s. Saturday's forecast calls for no rain, but the cold conditions are expected to remain.
The Twins lost to the Indians, 8-2 and 2-0, in Thursday's doubleheader, which lasted under five hours in game time. Minnesota outscored Chicago, 32-19, in three games the last time they were in town on Aug. 1-3.