The Mariners haven't held a season-opening game at Safeco since 2008, but they will host the Angels for a three-game set from April 6-8, then head to Oakland to start a six-game road trip before returning to Seattle for a nine-game homestand against the Rangers, Astros and Twins.
Starting on the road hasn't hurt the Mariners success rate on Opening Day in past years. Thanks in large part to Felix Hernandez's dominance, Seattle has won eight straight season openers, the longest streak in the Majors since the Reds won nine in a row from 1983-91. Hernandez has started seven of those games and is 5-0 with a 1.52 ERA.
The American League West matches up with the National League West in Interleague Play next year, and the Mariners will host the Padres (May 12-13), Giants (June 17-18), D-backs (July 27-29) and Rockies (Sept. 11-13).
The Mariners also travel for Interleague series against the Dodgers (April 13-15), Giants (June 15-16), Padres (June 30-July 1) and Rockies (Aug. 3-5).
The Mariners will play at home on Mother's Day (May 10 vs. Oakland), Father's Day (June 21 vs. Houston) and Labor Day (Sept. 7 vs. Texas). They'll host the Red Sox for four games from May 14-17 and the Yankees for three games from June 1-3.
The season concludes with a six-game homestand with the Astros and A's, with an afternoon game against Oakland closing the regular season on Sunday, Oct. 4.
The initial schedule is subject to change. The official MLB schedule and start times will not be finalized until January.
Greg Johns is a reporter for MLB.com. Follow him on Twitter @GregJohnsMLB as well as his Mariners Musings blog. This story was not subject to the approval of Major League Baseball or its clubs.