Fenway Park will open for business on April 13 for the start of a three-game series against the Nationals.
This is the second year in a row the Sox will play their home opener against a National League foe. The Brewers were the opponent in 2014.
The first homestand will also include a four-game series against the Orioles, which concludes with the annual Patriots' Day game at 11 a.m. ET.
The Yankees come to Fenway for the first time for a three-game series from May 1-3.
There will be two West Coast swings for the Sox next year, the longest being a two-city journey through Oakland and Seattle from May 11-17.
Boston won't go back west until July 17-20 for a four-game series at Anaheim that takes place right after the All-Star break.
Before taking the four-day break for All-Star festivities, the Red Sox will host the Yankees for a three-game series.
For their Interleague schedule, the Red Sox will only play NL East teams in 2015.
There will be a four-game home-and-home series with the Braves, which will start in Boston on June 15-16 before continuing on to Atlanta for the next two days.
The Sox play the Marlins at Fenway on July 7-8, and then again in Miami Aug. 11-12.
And for the first time in regular-season action, the Red Sox will play at Citi Field from Aug. 28-30. Boston was actually the first team to play at the Mets' new home stadium, but it was for exhibition games at the end of Spring Training in 2009.
The Phillies come to Fenway for three games from Sept. 4-6, marking the end of the Interleague schedule for the Red Sox.
The last regular-season homestand will be Sept. 21-27, against AL East opponents Tampa Bay and Baltimore.
A four-game series at Yankee Stadium from Sept. 28-Oct. 1 could be electric if there are postseason implications.
The 2015 Red Sox complete the regular season from Oct. 2-4 in Cleveland.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.