For the 13th time in the last 15 years and fourth year in a row, the Astros will open at home when they face the Indians in the first game of a three-game series to begin the 2015 season on April 6.
The 2015 season, which marks the 50th anniversary of the opening of the Astrodome, will see a handful of the Astros' former National League West rivals come to Minute Maid Park for the first time since the club switched leagues, including the Dodgers and Giants.
The Giants and Hunter Pence return to Minute Maid Park, May 12-13, and the Dodgers and Texas native Clayton Kershaw come to Houston from Aug. 21-23. Other Interleague matchups include series at San Diego (April 27-29) and at San Francisco (Aug. 11-12).
The Astros' series against the Giants at AT&T Park will cap a weeklong stay for the Astros in the Bay Area. They play in Oakland against the A's, Aug. 6-9, and will have an off-day before going across the bay to play the Giants.
The Rockies and Astros will play a split four-game series -- June 15-16 in Houston and June 17-18 in Denver.
The Astros will close the regular season on the road against an NL team for the second year in a row when they face Arizona in Phoenix, Oct. 2-4.
The Astros, who reclaimed the Silver Boot in 2014 by winning the Lone Star Series against Texas, will host the Rangers in three-game sets, May 4-6, July 17-19 and Sept. 25-27, with the latter two series falling on weekends.
The Yankees make their lone trip to Houston for four games, June 25-28, and the Red Sox visit Minute Maid Park, July 21-23.
Season tickets, group tickets and individual game suite rentals are on sale now for the 2015 season. Fans can purchase tickets by visiting www.astros.com.
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.