The Giants will follow that trip to Phoenix with a four-game visit to San Diego before they play their AT&T Park opener on Monday, April 13, against Colorado. That starts a 10-game homestand, which continues with four games against Arizona, April 16-19, and culminates with a three-game series against the archrival Los Angeles Dodgers, April 21-23.
San Francisco also will entertain Los Angeles on May 19-21 and Sept. 28-Oct. 1. The Giants will visit the Dodgers April 27-29, June 19-21 and Aug. 31-Sept. 2. They'll face the Dodgers and their other three National League West foes 19 times apiece.
The Giants will oppose NL West teams in their first 23 games, spanning the month of April.
The Giants will confront the cross-bay rival A's from July 24-26 at San Francisco and Sept. 25-27 in Oakland. San Francisco's other Interleague matchups also will be against American League West opponents.
The club's 10-game April homestand will be its longest, matched by an AT&T Park stretch against the Angels (May 1-3), Padres (May 4-6) and Marlins (May 7-10).
The schedule's most challenging portion for the Giants promises to be July 31-Sept. 9, when they'll play 27 of 39 games on the road. That stretch includes a pair of 10-game trips to Texas, Atlanta and Chicago from July 31-Aug. 9 and to Los Angeles, Colorado and Arizona from Aug. 31-Sept. 9.
Chris Haft is a reporter for MLB.com. Read his blog, Haft-Baked Ideas, and follow him on Twitter at @sfgiantsbeat. This story was not subject to the approval of Major League Baseball or its clubs.