After that, the Brewers will go on a long tour of the National League Central, with 22 consecutive games against intradivision opponents, including the Cardinals' opening series at Busch Stadium from April 13-16.
The Brewers will also finish with a slew of games within the division. From Aug. 28 through the end of the regular season on Oct. 4, 29 of Milwaukee's 35 games are against NL Central clubs. Just like this season, September 2015 will include a pair of three-city road trips (one to Cincinnati, Miami and Pittsburgh; and another to Chicago, St. Louis and San Diego) capped by a season-ending, three-game series against the Cubs at Miller Park.
Interleague Play will be confined to the middle months. The Brewers will host the White Sox (May 11-13), Royals (June 15-16), Twins (June 26-28) and Indians (July 21-22) while traveling to Detroit (May 18-20), Kansas City (June 17-18 as part of a four-game "home-and-home" series) and Cleveland (Aug. 25-26).
The two-game series in Cleveland comes amid a bizarre stretch in which Milwaukee has four off-days in the span of eight games, then plays 35 games in 37 days to finish the regular season.
The schedule announcement also included a new game time for some early-season getaway days. Games against the Reds on April 24, the Dodgers on May 7 and the Giants on May 27 that would have been at 12:10 p.m. CT in the past, will instead begin at 12:40 p.m.
The Brewers also have scheduled a handful of 6:20 p.m. CT games as part of a promotion with their flagship radio station, 620-AM WTMJ. Those games are April 20 against the Reds, May 4 against the Dodgers, May 11 against the White Sox and Sept. 3 against the Pirates.
The Brewers typically begin selling tickets to individual games in February. Further information about pricing and availability will be released at a later date.
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.