The potential pennant race will be heavy on the divisional games, as well. Twenty-five of the Tigers' final 31 matchups will be against AL Central foes.
Detroit will once again begin its Interleague slate early, visiting Pittsburgh starting April 13. All 20 of Detroit's Interleague games will be played against NL Central teams, as the Brewers, Cubs, Reds and Pirates all visit Comerica Park.
The Tigers will also head to Busch Stadium in St. Louis (for the first time since 2009), iconic Wrigley Field and Great American Ball Park -- a month before Cincinnati hosts the All-Star Game.
Detroit will get a reprieve from its West Coast travel, having played the NL West in Interleague this season. The Tigers' main West Coast swing comes at the end of May, when they go to Oakland for three games and then head to Los Angeles for four against the Angels.
The Yankees visit Comerica Park in April for four games. Boston comes to the Motor City in early August.
Detroit's 2015 regular season wraps up with an Oct. 1 off day followed by three games at the White Sox.
Matt Slovin is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.