"He says he's feeling better. But I think at the time you see it, the way it hit him and the way he was limping around, just being precautionary to take him out."
Carlos Sanchez was on first with two outs, when House's 1-2 slider caught Ramirez on the top of his foot. The White Sox shortstop tried to walk it off but fell to the ground in obvious pain. He departed after Schneider and Ventura checked on him, with Leury Garcia replacing him at first base and in the field at shortstop.
Once Ramirez reached the dugout, he fired his helmet against the wall in anger. Ramirez has played in 138 games, covering 1,203 innings. Ramirez's homer in the third inning, his 14th long ball and 65th RBI, tied the game against the Indians at 1.
There's a chance Ramirez could be back in the starting lineup Saturday night against Corey Kluber.
"It's possible," Ventura said.
Scott Merkin is a reporter for MLB.com. Read his blog, Merk's Works, and follow him on Twitter @scottmerkin. This story was not subject to the approval of Major League Baseball or its clubs.