Pino was optioned there on Friday and fared well in his start with the Red Wings on Monday, giving up just two runs on three hits over seven-plus innings to improve to 10-2 with a 2.47 ERA at Triple-A. Pino, 30, is 1-5 with a 5.37 ERA in 10 starts with the Twins this season.
Twins manager Ron Gardenhire wouldn't confirm it will be Pino, but strongly hinted at it on Wednesday, as Pino would be pitching on regular rest.
"I'm not trying to hide too much here," Gardenhire said. "Who's in line? Run with it."
Gardenhire also said that right-hander Trevor May will start Game 2 against the Tigers.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.