The team had been hopeful that Cabrera could avoid another DL stint, but an MRI revealed that the injury was not just a cramp, as the team had initially indicated when Cabrera was a late scratch on Sunday.
"He isn't going to be able to bounce back as quickly as we hoped," said Padres manager Bud Black. "After looking at the MRI [on Monday], our team doctors thought that … This is going to take a stint on the disabled list."
Cabrera missed 21 games in July with a strain just inches away from the current injury. He was reinstated on July 29 and had hit .350 in 40 at-bats since returning, but Cabrera aggravated the hamstring again while stealing a base in Saturday's 2-1 victory over the Pirates.
Alexi Amarista will likely see the majority of playing time at shortstop, as he did during Cabrera's previous trip to the DL.
Will Laws is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.