Valdespin was ruled safe and Price challenged the call. Upon replay review, it was decided that the call stood.
For his troubles, Frazier also came away sore from the play because Valdespin stepped on his foot when he touched first base. Cincinnati and pitcher Mike Leake worked out of the jam without a run scoring.
For the series, the Reds were 2-2 on Price's managerial challenges.
Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, and follow him on Twitter @m_sheldon. This story was not subject to the approval of Major League Baseball or its clubs.