Jurrjens was pulled with two outs in the fifth after Clayton Kershaw's RBI single made it an 8-0 lead for the Dodgers. The team clarified that Jurrjens' departure at that point was not due to ineffectiveness but he apparently struggled breathing all game.
"It sounds like he started having some trouble earlier in the game," Weiss said. "He was able to deal with it at that time, but I think it got worse."
Considering Jurrjens was acquired two days earlier from the Reds, Weiss suggested nerves and trouble acclimating to Denver's altitude could have played a part.
"People react differently when they get here with the altitude and everything, so I think that was part of it," Weiss said. "But everything was moving pretty fast for him. All of a sudden, he was here and starting in a big league game again. I'm sure things were spinning."
Jurrjens had previously made four starts at Coors Field during his time with the Braves but hadn't pitched in Colorado since 2010.
Making his first Major League start since June 29, 2013, Jurrjens surrendered 12 hits -- including two home runs -- and eight runs over 4 2/3 innings, striking out three in a 99-pitch outing.
Cody Ulm is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.