With two outs and the bases loaded, the Reds' Ryan Ludwick hit a ball to third baseman Chase Headley, who threw to second baseman Irving Falu for the forceout at second base as Todd Frazier was bearing down on him.
Frazier was ruled safe on a close play that Padres manager Bud Black opted to challenge. The umpires huddled before overturning the call, ruling Frazier out, thus ending the game.
"That was a bang-bang play. I just saw it on the big screen. It was close enough to challenge, we had our guys look at it and it was close," Black said. "So I popped out and thought we should challenge that.
"I'm glad it went our way."
Cincinnati manager Bryan Price obviously felt differently about the outcome.
"This is an 8-2 ballgame, it may be inconsequential, but that's not the way to end the game. It just isn't," Price said.
This marked the second time since full instant replay was instituted that a game ended with a call being reversed due to instant replay.
The previous game was on May 6 in a game between the Giants and Pirates when Pittsburgh's Starling Marte was originally ruled out at home plate with two outs in the bottom of the ninth inning. That overturned call gave the Pirates a 2-1 walk-off victory.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.