Farrell came out to challenge the play, and after a review of two minutes and 18 seconds, it was ruled a single, with David Ortiz moving to second.
The Mariners then wanted to challenge whether Robinson Cano had forced Ortiz at second base, but they were told that a second review wasn't necessary because the umpires had reviewed the actions of the baserunners in the first replay.
In the bottom of the fifth, Farrell challenged a play on defense, when starter Jake Peavy covered first in an attempt to complete a 3-6-1 double play off the bat of James Jones.
Following a review of two minutes and 42 seconds, the call stood and Jones was safe.
Of the 15 plays Farrell has challenged this season, nine have been overturned.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.