Nationals manager Matt Williams immediately ran onto the field, and the umpires initiated a review. After a replay review that lasted 41 seconds, the umpires overturned the call and ruled the hit a two-run home run, tying the game at 4.
"I thought I saw it hit the railing," Rendon said, "then bounce back onto the field."
Jayson Werth then walked before Adam LaRoche grounded out to first base to end the inning and send the game to extras.
In the bottom of the 11th, the umpires were forced to review a second play when Williams challenged an out call at first base.
Pinch-hitter Kevin Frandsen hit a chopper to the left side of the infield with one out and no runners on base. Third baseman Chris Johnson moved to his left, fielded and fired to first, but his throw was off target. Freddie Freeman came off the bag and caught the errant throw before tagging Frandsen, who fell to the ground to try and avoid Freeman's glove. But the umpires ruled Frandsen out on the tag.
Williams challenged the play, and after a replay review that lasted one minute and 30 seconds, the call was confirmed for the second out of the inning.
The Nationals went on to lost the contest, 6-4, in 13 innings.
Daniel Popper is an associate reporter for MLB.com. He also can be found on Twitter @danielrpopper. This story was not subject to the approval of Major League Baseball or its clubs.