But the throw from White Sox catcher Tyler Flowers was strong with shortstop Alexei Ramirez applying the tag. Cabrera was ruled out on a close play.
San Diego's Bud Black issued his manager's challenge but the call eventually stood.
The White Sox, trailing 3-1 at the time, wouldn't allow a run to score in the inning.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.