After a review of one minute and 30 seconds, the call was overturned and Bonifacio was ruled safe, giving Chicago a 9-2 lead over St. Louis. He was able to slide under catcher Yadier Molina's tag.
It was the 17th challenge by the Cubs, and they have now won nine of them.
Carrie Muskat is a reporter for MLB.com. She writes a blog, Muskat Ramblings, and you can follow her on Twitter @CarrieMuskat. This story was not subject to the approval of Major League Baseball or its clubs.