Clemens returns for his second stint with the Astros this season. The right-hander made four appearances with Houston in April and posted a 4.73 ERA over 13 1/3 innings.
Oberholtzer made the Opening Day roster and started seven games, but the left-hander went 0-6 with a 5.68 ERA.
Cisnero has been with the Astros since being recalled from Triple-A on April 25. He made five relief appearances before his injury.
Austin Laymance is a reporter for MLB.com. Follow him on Twitter at @jalaymance. This story was not subject to the approval of Major League Baseball or its clubs.