Right-handed hitter Howard Kendrick will start at second base over switch-hitter Maicer Izturis while catcher Mike Napoli, who has five hits in nine career at-bats against Pettitte, will be behind the plate instead of Jeff Mathis.
Kendrick, who is 4-for-16 lifetime against Pettitte, will bat seventh and Napoli will bat eighth ahead of shortstop Erick Aybar.
Escape from New York: The Halos head to Angel Stadium down 0-2 against the Yankees, and history isn't exactly on their side. Only three of the 20 teams that lost the first two games of the series since the ALCS became a best-of-seven format in 1985 have gone on to win the series.
This is the fifth time the Angels have fallen behind 0-2 in the postseason, and they've yet to come back from that deficit. But they are 8-4 in Game 3s in the postseason.
Pettitte brings experience: Pettitte is just one win away from having the most wins in the history of the postseason as he currently has 15 wins in the playoffs to tie John Smoltz. The left-hander is 15-9 with a 3.89 ERA in 36 career postseason starts, which is the most all-time.
Pettitte, though, has struggled against the Angels in his career, with a 12-10 record and a 4.70 ERA, including an 0-2 record and 7.88 ERA against them this season.
Home cookin': Angels right-hander Jered Weaver loves pitching at Angel Stadium, and it shows. He is 27-12 with a 3.27 ERA in 53 career starts at home and was 9-3 with a 2.90 ERA there at home this season.
He has also pitched well in the postseason in three career appearances, with a 1.88 ERA after allowing three earned runs in 14 1/3 career innings in the postseason.
A new Mr. October?: Alex Rodriguez has three home runs so far in the postseason, and all three have tied the game or put the Yankees in the lead. It's a trend that carried over from the regular season, when 15 of his 30 homers tied the game or put the Yankees ahead.
After a slow start and some noted struggles in past playoff series, Rodriguez now has a .294 batting average with nine home runs and 24 RBIs in 43 postseason games.
No break for Yankee Stadium: The Yankees announced that Yankee Stadium will open the Stadium Field Level and Great Hall to the public to watch the broadcast of Game 3 from Anaheim on Monday.
Gates 4 and 6 will open at 3:30 p.m. ET for the 4:13 p.m. start, with food and concession stands open for the fans.
Rhett Bollinger is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.