Cespedes limped off the field with a trainer by his side, after legging out an infield base hit in his fifth plate appearance of the night. Josh Reddick entered the game to pinch-run for Cespedes.
On Friday, with right-hander Brad Peacock slated to pitch for the Astros, Melvin said he expects to play Brandon Moss in left field and Daric Barton at first base.
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. This story was not subject to the approval of Major League Baseball or its clubs.