Double-A San Antonio of the Texas League is on the road in Springfield, Mo. The Missions will use a six-man rotation, with Matt Wisler and Jesse Hahn piggybacking each other followed by Josh Geer, Devin Jones, Justin Hancock and James Needy.
Class A Advanced Lake Elsinore of the California League opens the season Thursday in Lancaster. The starting rotation will be Joe Ross, Zach Eflin, Colin Rea, Ruben Mejia and Bryan Rodriguez.
Class A Fort Wayne of the Midwest League is the only Padres' affiliate to open at home. The TinCaps will face Great Lakes. The TinCaps will also use a six-man rotation with Walker Weickel, Payton Baskette, Pete Kelich, Yimmi Brasoban, Walker Lockett and Adrian DeHorta.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.