Sale makes his fourth start of the spring, while Kershaw will get in his final Spring Training start before his Opening Day assignment in Australia.
Another intriguing pitching matchup can be seen at 7:05 p.m. ET on MLB.TV between two talented left-handers. Phillies veteran Cliff Lee will face Red Sox ace Jon Lester at JetBlue Park.
Lee's had an excellent spring, striking out 10 and walking just one in 8 2/3 innings. Meanwhile, Lester has eased into pitching this spring, making his first start on Monday. He allowed one hit and struck out four in three innings against the Rays.
"I felt good," Lester said after the start. "It felt good to get the first one out of the way. Kind of what we talked about last week as far as getting used to the surroundings and the fans and the whole routine of a normal work day. It was good. It was a step in the right direction going through spring."
In a split-squad game between the A's and the Giants at 6:05 p.m. ET on MLB.TV, Matt Cain looks to continue his unbelievable spring. He'll be up against Tommy Milone, who is trying to make the A's Opening Day roster.
In two Cactus League starts, Cain has allowed just one hit, zero walks and has nine strikeouts in eight innings. In his last start against the Cubs, Cain pitched five perfect innings.
"I threw good pitches when I was ahead on the count, which is always nice," Cain said after the start. "At times, you feel like you get in good counts and you're not able to finish guys, but today we were able to do that."
Angels ace Jered Weaver gets the nod in a 4:10 p.m. ET contest against the Rockies and Juan Nicasio, which can be seen on MLB.TV. The right-hander struggled on Monday against the Indians in his third start of the spring, allowing three runs on five hits in 4 1/3 innings. However, he did end the outing by striking out three of the last five batters he faced.
Royals Opening Day starter James Shields has been no stranger to success this spring. Shields is 2-0 with a 1.04 ERA with no walks and eight strikeouts in 8 2/3 innings. He makes his fourth Cactus League start against the Cubs at 4:05 p.m. ET on Gameday Audio.
Quinn Robertsis a reporter for MLB.com This story was not subject to the approval of Major League Baseball or its clubs.