Reds manager Bryan Price challenged, and after a review of 2 minutes, 15 seconds, the call was upheld by umpire Gerry Davis, viewing it on site in a truck. Under the new rule, Price lost his ability to challenge another play before the seventh inning, although the umpires can use their discretion to have any play reviewed.
Conger scored three batters later on a single from Kole Calhoun.
"It worked out really well, actually," Price said. "We didn't get the call overturned, but we got a chance to have more dialogue with the umpires. As far as the protocol goes, going out there and engaging and kind of understanding the dos and don'ts. One thing that was terrific was that they kind of conferred first so that we didn't have to unnecessarily use a challenge if maybe [another] umpire had a clearer vantage point and overturned that call before using a challenge. And that puts the onus on the other manager. Pretty interesting stuff."
During the regular season, all calls will be made by an umpiring crew stationed in a replay studio at Major League Baseball Advanced Media offices in New York.
"It's getting less confusing as we're absorbing it and trying it," Angels manager Mike Scioscia said. "I think the whole logistics of seeing the replay and getting it to the umpire will be better during the season because of the ability to see the play from many angles, hopefully, in a timely fashion from New York."
Making his third start of Cactus League play, Cueto allowed just two hits over four innings with two strikeouts.
The Reds managed just five hits against seven pitchers.
Tyler Skaggs gave up just one hit and two walks in four innings to bolster his bid for the fifth spot in the Angels' rotation.
The Reds scored their run on back-to-back doubles from Kristopher Negron and Rey Navarro in the eighth.
Up next: The Reds head to Surprise Stadium to face the Rangers on Monday at 4:05 p.m. ET in a matchup that can be heard live on Gameday Audio. Homer Bailey takes the mound opposite Texas ace Yu Darvish. Jeff Francis, Jumbo Diaz, Lee Hyde, Carlos Contreras and Michael Lorenzen also are slated to pitch for the Reds.
Chris Gabel is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.