Arizona pitcher Randall Delgado allowed four runs on five hits with one walk and two strikeouts over 3 2/3 innings.
Delgado got the start Tuesday in place of scheduled starter, Bronson Arroyo. Arroyo has a stiff back and was scratched late Monday. Delgado had been scheduled to throw in a simulated game Tuesday.
Each one of these Cactus League appearances are important for Delgado, who is out of Minor League options and will likely open the season in the bullpen, especially if Archie Bradley wins the job as the team's fifth starter.
San Diego pitcher Eric Stults struggled for the second time this spring. He allowed three runs on three hits with two walks in the first inning and needed 43 pitches to get three outs.
Quentin's home run off Delgado came in his first at-bat of the spring and his first at-bat since July 30 of last season, which was right about when he was shut down for the season with a right knee injury that eventually led to surgery.
"It was a good swing on the 3-0 pitch, that's how you do it on 3-0," Padres manager Bud Black said of Quentin. "He was looking fastball and put a good swing on it. He's felt good all spring building up to this game. We're happy where he's at after his surgery this offseason. He'll continue to build his endurance and stamina."
Paul Goldschmidt had two hits and scored three runs for the D-backs.
Up Next: Andrew Cashner will make his second start of the spring Wednesday when the Padres face the White Sox at Camelback Ranch at 12:05 p.m. PT. Cashner tossed two scoreless innings his last time out against the Mariners, recovering well after allowing a hit and a runner to reach on an error before uncorking a wild pitch. He worked out of that jam and then worked a quick second inning. He'll likely throw three innings Wednesday. Cashner is considered the favorite to start Opening Day against the Dodgers on March 30, though Black has yet to name a starter.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter.
This story was not subject to the approval of Major League Baseball or its clubs.