Manager Don Wakamatsu was well aware of Griffey's situation two hours before game time but appeared confident the veteran slugger would be able to play in the second of Seattle's four-game set against Oakland.
"We're going to watch him during batting practice," the skipper said. "I imagine he's going to play."
Less than one hour later, though, Griffey was replaced by Mike Sweeney in the designated hitter spot.
In Thursday's 7-4 win over the A's, Griffey grounded out three times and struck out once. The 39-year-old designated hitter underwent an MRI on his surgically repaired knee Tuesday, and Wakamatsu felt confident everything looked normal.
Jane Lee is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.