The rotation includes former Cy Young Award winners Jake Peavy and Randy Jones while the all-time leader in saves, Trevor Hoffman, is set to be the club's closer.
It's sure to be an exciting segment as TWIB interviewed several of the players on the list and compiled video and stats for all the players during their Padres career.
"It's a fast-paced piece because it's getting in a lot of guys with sounds and calls with relevant stats too," TWIB lead producer Matt Anderton said. "So it'll be fast and lively and set to music. It's basically profiling these guys, who we determined were the all-time Padres lineup."
Next, TWIB takes a look at the Padres' current closer, Heath Bell, who replaced Hoffman this season. But Bell has shined in his new role as he currently leads the National League in saves.
"Bell's having a great season even though replacing Trevor Hoffman is a monumental task," Anderton said. "He's handling it very well. And he's a great guy."
Bell also talks to TWIB about his secret to losing weight last off-season when he played a video game with his children called Wii Fit, which allows gamers to exercise using a balance pad that comes with the game.
Next up, TWIB announces the winners of two awards as White Sox left-hander Mark Buehrle was named the Pepsi Clutch Performer for July after throwing a perfect game on July 23 while Cardinals first baseman Albert Pujols was named the winner of the Roberto Clemente Award for 2008.
Pujols won the award because of his charity work as the Roberto Clemente Award honors the player that "best exemplifies the game of baseball, sportsmanship, community involvement and the individual's contribution to his team", as voted on by baseball fans and members of the media.
"We show great elements of his charity work with his golf tournament and his work with kids with down syndrome," Anderton said. "And we talk to him and his wife about his work."
TWIB can be seen on video board in stadiums, as well as internationally in Australia, Canada, Cuba, Dominican Republic, Guatemala, Japan, Latin America, Middle East, The Netherlands, Antilles, Nicaragua, Panama and Taiwan.
Viewers can e-mail the show at email@example.com, and can check out the Web site, TWIB.com, for original blogs and bonus footage. There will also be a re-airing of the show on MLB Network at 12:30 p.m. ET on Sunday.
Here are some of the other segments TWIB will feature in its half-hour show this Saturday:
Holiday Inn "Win on the Road" will focus on the team with the longest current road winning streak -- in this case, the Padres, who won five straight games away from Petco Park.
The XM "Call of the Week" focuses on the Rockies' Troy Tulowitzki, who hit for the cycle on Monday against the Cubs.
The State Farm "Big League Blast" features Angels slugger Vladimir Guerrero's 400th career home run that came Monday against the Rays.
The Gillette "Rookie of the Month" segment will focus on the Diamondbacks' Trent Oeltjen, who homered in his first career game on Aug. 6 against the Pirates.
"How 'Bout That" will show the top plays and bloopers from the previous week.