Crow put Santiago in an 0-2 hole with two called strikes on the outside corner before leaving a slider up and in. Santiago turned on it and sent it out to right for the Tigers' second hit of the game and first run of the afternoon.
It marked Santiago's first home run since he took Cincinnati's Bronson Arroyo deep on June 9, 2012, at Great American Ball Park. His only other home run last year was a shot down the left-field line off the Yankees' CC Sabathia on June 1.
Santiago became the first player with two career home runs off of Crow, who in turn became the third Major League pitcher to give up two homers to Santiago. Scott Kazmir and Gavin Floyd are the others.
Jason Beck is a reporter for MLB.com. Read Beck's Blog and follow him on Twitter @beckjason. Bobby Nightengale is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.