Quentin hurt himself sliding awkwardly into home plate on Monday, scoring on a sixth-inning single vs. the Cardinals.
"He's ready to go, he's encouraged with how he feels," Padres manager Bud Black said. "He's ready."
Even though the injury isn't on the same knee that was surgically repaired in 2012, the Padres will remain cautious with Quentin given his medical history.
"With Carlos, we're going to pay special attention to his knees on a regular day-to-day basis," Black said. "There are periods of time where he feels good and others when it's cranky. That's when you take a little step back."
In 30 games entering Friday, Quentin was batting .178 with four homers and 14 RBIs.
Tyler Emerick is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.