Webb won the 2006 National League Cy Young Award and was a three-time All-Star for the D-backs from '03-09.
In his final big league appearance, Webb was forced to leave his 2009 Opening Day start with shoulder soreness. The injury eventually required a pair of surgeries and despite numerous comeback attempts, and Webb never made it back.
Just before Spring Training this year, Webb announced his retirement.
D-backs second baseman Aaron Hill will also be presented with his 2012 Silver Slugger Award.
Limited tickets remain for the opener.
Steve Gilbert is a reporter for MLB.com. Follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.