Hultzen -- a first-round pick by the Marines in last June's First-Year Player Draft -- started against the Tribe and piled up four strikeouts with two walks and one hit in two innings of work. Walker, who was Seattle's first-round pick in the 2010 Draft, followed that performance by striking out two and giving up no hits in his two frames.
Indians starter Brett Myers, who signed a one-year contract with the team over the winter, allowed one run on two hits across three innings in his second outing of the spring. Peguero provided the lone breakthrough against Myers by drilling a 3-1 offering over the wall in left field for a one-out solo home run in the third inning.
Peguero -- a candidate for a backup outfield role with Seattle -- added a second blast in the fourth.
Facing Indians rotation hopeful Corey Kluber, the 6-foot-5, 260-pound Peguero sent a 1-2 pitch out to right field for his second shot of Spring Training. His two home runs upped the Mariners' Cactus League-leading total to 12 homers this spring.
Kluber, who is competing for the fifth spot in the Cleveland rotation, surrendered three runs on five hits with a pair of strikeouts in two innings.
Mariners first baseman Kendrys Morales (acquired from the Angels in an offseason trade) delivered his first hits as a member of Seattle. After opening the preseason slate with an 0-for-5 showing, Morales came through with a leadoff single in the second inning and another base hit in the fourth. Also in the fourth inning, Michael Saunders contributed a run-scoring single for the Mariners.
In the top of the eighth inning, there was a five-minute delay due to a false fire alarm at Goodyear Ballpark.
Up next for Mariners: Jon Garland will make his first Major League appearance since 2011 when he starts against the Giants in a 1:05 p.m. MT (12:05 p.m. PT) game in Scottsdale, Ariz. The veteran right-hander is trying to crack the Mariners rotation as a non-roster invitee as he comes back from shoulder surgery.
Garland is expected to throw one inning and then be replaced by Blake Beavan, who is scheduled to throw three frames in his second spring outing. Erasmo Ramirez is also slated for two innings, followed by closer Tom Wilhelmsen and hard-throwing youngster Carter Capps.
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. This story was not subject to the approval of Major League Baseball or its clubs.