Biden will be the first sitting vice president to throw out a first pitch at Oriole Park, the club said in its announcement on Monday morning.
The Orioles and Yankees are scheduled to play at 4:05 p.m. ET, with pregame ceremonies scheduled to begin at 3:30.
Biden was a U.S. Senator representing neighboring Delaware for 36 years prior to his election as vice president in November.
Bobbie Dittmeier is an editor/producer for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.