The news was reported by KKLA, a Christian radio station in Glendale, Calif., which has carried "The Frank Pastore Show" since 2004.
Pastore, who was 55, was reportedly struck by a car on Interstate 210 in California and sustained head trauma. He was taken by medical helicopter to a local hospital.
A right-hander, Pastore had a 48-58 record and 4.29 ERA in 220 career games over eight Major League seasons. Drafted by Cincinnati in the second round in 1975, he spent most of his eight-year career with the Reds from 1979-85 before finishing with the Twins in 1986.