The shift seemed to agree with the 23-year-old slugger, who went 3-for-5 with a solo homer and a two-run double as the Rafters beat the Mesa Solar Sox for the second day in a row, 11-3.
Salt River jumped out to an early lead, scoring four runs in the first inning. Matt Davidson (D-backs) launched a three-run homer before Skole, the Nats' No. 12 prospect, went back-to-back.
Davidson and Skole teamed up again in the fourth, with the D-backs' No. 4 prospect singling home Brian Goodwin and scoring on a two-run double by Skole, who singled again in the eighth.
Wrapping up his second year of pro ball, Skole batted .291 in 119 games between Class A Hagerstown and Class A Advanced Potomac. He was named South Atlantic League MVP, led Nationals farmhands with 27 homers and ranked second in the system with 104 RBIs.
Skole posted a .919 fielding percentage at third base, committing 23 errors. Last year with short-season Auburn, he made 14 errors in 155 chances (.910).
Goodwin, Washington's top offensive prospect, was 2-for-5 with a solo homer and Midwest League MVP Kevin Pillar (Blue Jays) reached base three times and slugged his first Fall League homer.
Cleanup hitter Jonathan Singleton -- a key part of the deal that sent Hunter Pence from the Astros to the Phillies in 2011 -- accounted for all of Mesa's runs. MLB.com's No. 25 overall prospect homered, tripled and plated three runs.
Southern League All-Star Chase Anderson (1-0) started for Salt River and gave up a run on two hits and two walks while striking out two in 2 2/3 innings. Solar Sox counterpart and Orioles right-hander Mike Wright (0-1) lasted one inning and was charged with four runs -- three earned -- on four hits.
John Parker is a contributor to MLB.com. Ashley Marshall contributed to this report. This story was not subject to the approval of Major League Baseball or its clubs.