"I don't know if I can be a Minor League director or I could be a front-office guy," Guillen said. "Because all the guys I see throw the ball well, 'Let's go to the big leagues.'
"I think, when you're a pitcher, why not burn the bullets in the big leagues? Burn them here, see what happens. It was an outstanding performance."
Ramos worked the ninth inning, striking out Rickie Weeks, Ryan Braun and Aramis Ramirez in order.
He became the first Marlins reliever to strike out the first three batters he faced in his big league debut.
Ramos is the fourth pitcher to do that this season. Pittsburgh's Justin Wilson (Aug. 20), San Diego's Tommy Layne (Aug. 14) and Minnesota's Tyler Robertson (June 26) were the others.
"He wasn't scared," Guillen said. "Your first game in the big leagues, you're very emotional. This kid was calm. He did what he did."
Guillen plans on giving Ramos a good look this month. The manager even joked that closer Steve Cishek better take notice.
"Right now, after I see what I see last night, watch out Cishek," Guillen said. "You will see him a lot in the game. Obviously, we're taking a risk with the kid. He will give up some runs. Hopefully not."
Ramos received two baseballs from his debut. Actually, it was adventurous to get them.
Normally, the first strikeout ball will be tossed to the dugout. But rookie catcher Rob Brantly instead threw the ball around the infield after Weeks struck out. Ramos used the same ball to strike out Braun. Again, the ball was thrown around, but the dugout screamed for it.
And it was thrown into the dugout before Ramirez stepped to the plate.
After fanning Ramirez, Brantly tossed the ball into the seats above the Marlins' dugout. Again he was hollered at, and Brantly exchanged the ball with a child.
The Marlins are putting together a display with the two baseballs for Ramos, who will give it to his parents.
Growing up, Ramos would dream about the perfect debut scenario. He achieved it.
"I'd be sitting in my room, thinking, 'Man, it would be cool if in my debut I struck out the side,'" he said. "It actually happened. It was kind of crazy."