The Padres did knock 11 hits against the Reds, but they also took 11 walks, many on close calls. They had three walks in their five-run second inning and two more in a four-run third.
"To do that in the big leagues, you're going to have to lay off some close pitches. We had some good at-bats and got some big hits in big situations," said Padres third baseman Chase Headley, who worked four free passes.
After falling behind, 3-0, in the first inning, the Padres scored nine runs over the next two innings, with five runs coming in the second and four more in the third.
Carlos Quentin had a two-run single as part of that five-run second inning. Will Venable had the big hit in the third inning -- a two-out, two-run triple to the gap in left-center field as the Padres ran out to a 9-3 advantage. Quentin later added a home run in the eighth inning.
"That was a great start for us," Reds manager Dusty Baker said of his team's three-run first. "The next inning, everything kind of exploded or imploded on us. We just had a number of walks tonight, which isn't like our guys. It seemed like we were dragging out there."
The celebration in the visiting clubhouse was somewhat muted after rookie catcher Yasmani Grandal left the game in the second inning with a strained right oblique, an injury he suffered taking a swing against Reds reliever Alfredo Simon.
"I don't think it's that bad. We are going to see what happens tomorrow. But I think I'll be OK," Grandal said.
There's no way to know how much time Grandal -- who was hitting .312 with five home runs and 15 RBIs in his first month in the big leagues -- will miss with the injury. Last season, catcher Nick Hundley missed 31 games with a strained oblique. Reliever Luke Gregerson had a similar injury and missed 25 games.
"It just depends on the degree of the strain," said Padres manager Bud Black.
Yonder Alonso tied a club record with his three doubles in the game. Quentin drove in three runs, one on his 10th home run with the team. Venable knocked in four runs.
Alonso, who was playing in his first game in Cincinnati after the December trade from the Reds brought him to San Diego, finished with four hits.
"Since Day 1, I've talked about Yonder's style ... it's truly line to line," Black said. "This guy is tough to defend."
It was a struggle at times for Padres pitcher Edinson Volquez, though he did manage to redeem himself after allowing three runs in the first inning.
How did Volquez manage that? By doing the one thing his counterpart, Reds starting pitcher Mike Leake, failed to do -- throw strikes, and somehow, despite not having great stuff, stay in the game.
Volquez, who entered the game with the lowest run support in the Major Leagues, pitched his way through five innings, though it wasn't easy. He yielded five runs on three walks and six hits, including a pair of home runs.
But this still rated as a gratifying night for Volquez, who like Alonso, was part of the five-player trade the Padres and Reds made in December to send pitcher Mat Latos to Cincinnati.
"I was trying to make better pitches [after the first inning]," Volquez said. "I know this ballpark and how the ball carries and I wanted to keep the ball down."