Holliday, hitting .321 with 25 home runs and 88 RBIs, has been dealing with back issues recently. He didn't play in the Rockies' final two home games of the season, last Saturday and Sunday, against Arizona because of back stiffness.
Spilborghs entered Friday night's contest with a seven-game hitting streak.
Thomas Harding is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.