Fellow rookie David Phelps took the loss, but Cory Wade took the beating, matching Warren with six runs allowed in 2 1/3 innings, albeit with 154 more big league appearances under his belt. That's how Wade has pitched for much of the past month.
The right-handed Wade posted ERAs of 1.69 in April and 2.92 in May, but his outing on Friday raised his June ERA to 13.97. He has allowed runs in five of his past six outings, and this one was the worst.
Wade entered in the seventh, after Phelps bridged most of the gap from Warren with a little help from Clay Rapada, who got the final out of the sixth to strand two men. Wade promptly allowed a two-run homer to Alexei Ramirez, then allowed four more runs in a sluggish ninth inning that saw Chicago spray hits across the outfield.
"He's just not locating as well, and he relies on location," Girardi said. "He's been up in the zone at times, and that's not who he is. It's been a struggle for him the last month."
Girardi had right-hander Cody Eppley warming in the ninth, but with the game well out of reach, he instead turned to outfielder Dewayne Wise.
Girardi asked Wise if he was willing to pitch about two minutes before the veteran entered the game, Wise said, enough time for him to throw six warmup pitches in the batting cage beneath Yankee Stadium under the watchful eye of fellow left-hander CC Sabathia. It worked, as Wise took over for Wade and recorded the final two outs.
More than saving a bullpen, it helped save the Yankees' spirits.
"We got our butts kicked tonight," said Wise, who last pitched during his sophomore year of high school. "But it's just one game, and I came in and everybody kind of laughed about it."
It was one of few bright spots since the first inning, which began with Warren escaping a jam after a pair of walks for a scoreless first frame, then saw the Yankees take a 4-0 lead.
Derek Jeter sent the second pitch he saw from White Sox starter Jose Quintana, who spent the past four years in the Yankees organization, down the left-field line to pass Cal Ripken Jr. for 13th place on the all-time hits list with No. 3,185. Curtis Granderson followed with a homer, and Andruw Jones added a two-run double.
But Girardi admitted on Friday afternoon that it's impossible to predict how a pitcher will perform in his Major League debut, and he could only hope Warren would get through his first big league inning, then settle in.
Quintana settled in, but Warren did not.
"The biggest thing is I battled," said Quintana, who became a Minor League free agent this offseason when the Yankees did not add him to their 40-man roster. "Once I saw the guys were hitting balls and trying to get me support, that gave me more energy to go out there."
Warren -- a fourth-round pick in the 2009 First-Year Player Draft who had about 12 family members and friends in the crowd of 44,265 -- allowed leadoff home runs in both the second and third innings, and four additional runs in his brief debut.
"It was a sigh of relief getting through that first inning," said Warren, who admitted to fighting nerves but said they went away after he escaped the first. "I went out for the second inning and just found it hard to find a rhythm."
The Yankees took Warren off the hook for a loss with a two-run double from Jayson Nix in the fourth that temporarily tied the score, but A.J. Pierzynski led off the fifth with his second homer of the game to give Chicago a lead it would not relinquish.
"It's a bad night; every team has them," Girardi said. "They just had 21 hits in Minnesota the other night, I believe, too, so this is a club that can really hit. They hit the ball out of the ballpark. I wouldn't be too quick to form a judgment [on the Yankees' pitchers]."