In the last meeting, both hurlers went seven full innings without a run and gave up just six hits between the two of them.
"Every game is a different game," San Diego manager Bud Black said. "There's really no reason to expect anything different from another game. Every game is a blank canvas; you never know how it's going to be played out."
On a hot, humid night in Milwaukee, the Brewers and Padres combined for six home runs and a total of 12 extra-base hits. With the ball carrying out of Miller Park, Marcum said it was a much different feel Friday night than his last time out against the Padres.
"When you're pitching in San Diego, you can throw stuff down the middle and let them hit it as hard as they can, and there's times when it's not going to go out," Marcum said. "It's definitely a different type of ballpark, and we were able to use it to our advantage on some, and able to come out on top."
The Brewers hit four of the game's six home runs, starting with first baseman Corey Hart's solo shot off Volquez three pitches into the bottom of the first.
Marcum, meanwhile, cruised through the first two innings, striking out three of the first six batters he faced. However, after Padres catcher Nick Hundley flew out to left to start the third, shortstop Everth Cabrera stepped to the plate and hit a line drive to center field. The ball dropped under the glove of Carlos Gomez and rolled all the way to the wall, as Cabrera circled the bases and came home to score for San Diego's first inside-the-park home run since Aug. 5 2010.
Cabrera, according to Black, was one of the bright spots Friday night, going 2-for-3 with both hits going for extra bases.
"I'm seeing good swings," Black said of Cabrera. "He hit the ball on the nose three times tonight."
Cabrera sent another run across the plate when he walked with the bases loaded in the fourth inning, putting the Padres ahead 2-1.
Fortunately for Milwaukee, Marcum induced a Volquez groundball to end the inning without any more damage. Unfortunately for San Diego, Volquez would not be so lucky in the bottom half.
After Brewers second baseman Rickie Weeks made it to third base on two wild pitches and shortstop Cody Ransom reached on a walk, Volquez did find a little good fortune when Ransom was thrown out at third on a Gomez fielder's choice. But with runners on the corners and two outs, Milwaukee catcher Martin Maldonado blasted a three-run homer to left field to give the Brewers the lead, 4-2.
"I threw a mistake, and that was the whole game," said Volquez, who dropped to 2-6 on the year. "I pitched a little different with the pitcher on deck. I threw a first-pitch breaking ball and a second-pitch fastball. It was a bad pitch."
Black described Maldonado's home run as a "backbreaker." After taking some momentum from the Brewers, the Padres gave it right back. The very next inning, Volquez gave up two more runs on Hart's second home run and an Aramis Ramirez groundball that scored right fielder Norichika Aoki.
Center fielder Cameron Maybin's solo shot in the top of the sixth trimmed the Brewers' lead to three, but it wouldn't be nearly enough, as Milwaukee added three more runs in the seventh.
Friday marked the third straight loss for the Padres, who move to 5-20 on the road, and the fourth in their last six games. It was also the sixth straight game San Diego gave up four or more runs, including the second consecutive time giving up eight or more.
On the flip side, Black has been happy with the progress he's seen from the offense, and said it's a matter of putting it all together.
"Our starting pitching has been a little bit erratic, variable," Black said. "We haven't had that one really dominating outing, which you need to maybe gain some momentum. But offensively, we're seeing some good things out of a number guys."