Pavano allowed seven runs (six earned) on nine hits and a walk over 3 2/3 innings to mark his shortest outing of the season.
He stopped short of saying he'll need to be placed on the disabled list after the game, but it sounded like there's a chance it could happen after he meets with manager Ron Gardenhire and pitching coach Rick Anderson on Saturday.
"I think it's coming time where decisions need to be made," said Pavano, who is 1-4 with an 8.25 ERA over his last five outings. "I need to give myself a chance. This has gone on long enough. My stuff is not what we're used to seeing from me. I wish I could say it was a rough patch. But I'm really treading water right now. Some decisions need to be made whether or not I'm going to keep battling through this or give myself a chance."
Pavano had trouble keeping the ball in the park, as he served up a two-run homer to Lonnie Chisenhall in the second and a grand slam to Jason Kipnis in the fourth.
Gardenhire confirmed he'll talk with Pavano before deciding what to do with the veteran right-hander, who continues to scuffle.
"It's been a struggle for him so far," Gardenhire said. "We'll see where we go from here. We'll discuss all those things after the ballgame and figure out tomorrow where we're at with him."
Chisenhall was the first to go deep with a two-run shot on an 0-2 slider after Johnny Damon singled with two outs.
"It was down," Pavano said. "I think it went right into his swing. It was 0-2 and he put a good swing on it. I threw it in a spot where sometimes you get away with it, but just [didn't] turn out that way. A lot of pitches didn't turn out that way today."
Michael Brantley added an RBI double with two outs in the third after Jose Lopez reached on a throwing error from third baseman Jamey Carroll.
Kipnis provided the big blast in the fourth, as his first career grand slam came after Chisenhall singled, Lou Marson walked and Shin-Soo Choo singled with one out.
Lowe, meanwhile, continued his mastery over Minnesota this season. Lowe, who shut out the Twins on May 15, surrendered one run on five hits and a walk over 6 1/3 innings.
"This time around, they were a lot more patient, waiting to get balls up," Lowe said. "But it seemed like as the game went on, they got a little bit more aggressive. Maybe it was the score of the game, but they did a very good job of trying to work counts and hit the ball the other way. We threw a couple more breaking balls that we normally don't throw."
The Twins didn't get on the board until the seventh inning, when Brian Dozier laced an RBI single to score Josh Willingham, who singled and reached second on an infield hit from Ryan Doumit.
"We've just had a tough time hitting him," Dozier said. "He's a veteran. He knows what to do. He had his sinker again tonight. I don't think it was sinking as much as it did the first time we played him, but when you can spot up as good as he did, it doesn't really matter how much it sinks."
But Dozier's RBI was the only offense the Twins could muster, as they saw their three-game winning streak come to end.
"We came in with some momentum and I killed it right away," Pavano said. "By the fourth inning, we're down seven, that's no way to start a series."