The contract of right-hander Cole De Vries, a 27-year-old from Eden Prairie, Minn., was purchased from Triple-A Rochester before Tuesday night's game against the White Sox.
Marquis was 2-4 and yielded 52 hits, 32 earned runs with 14 walks and 12 strikeouts over 34 innings across seven starts this season. He signed a one-year, $3 million deal with the Twins in December.
"He went through an awful lot, but bottom line, it wasn't working out here for him," Twins manager Ron Gardenhire said. "[He] just wasn't getting it done out in the field."
Marquis' Spring Training was interrupted when his daughter was injured in a bicycle accident in New York, and he wasn't able to get on track since. The Twins have 10 days to trade, release, or, if Marquis allows after passing through waivers, outright him to the Minors.
The 33-year-old has pitched in the Major Leagues for 13 seasons, compiling a 106-102 record and a 4.63 ERA. He was an All-Star in 2009, when he went 15-13 for the Rockies.
"He's got a lot of experience, and hopefully he'll catch on with somebody else," Gardenhire said. "This is time for him to regroup a little bit, we're going to go another route."
Evan Drellich is a reporter for MLB.com. Follow him on Twitter @EvanDrellich. Cash Kruth is a reporter for MLB.com. Follow him on Twitter at @cashkruth. This story was not subject to the approval of Major League Baseball or its clubs.