One error in the 10th happened when the White Sox Carlos Quentin lined a sharp grounder to Uggla and the ball trickled between Uggla's legs for a single.
"That was a rough one," Uggla said. "I'm not going to lie. Sometimes it's not your night. Tonight wasn't my night. You move forward, you take those. No excuses, but stuff like that happens."
After the errors in the 10th, an intentional walk loaded the bases with one out. But Colorado pitcher Aaron Cook got out of the jam, and Uggla took a deep sigh of relief.
Uggla said he wasn't pressing, and he remained upbeat about playing in the last All-Star Game in Yankee Stadium.
"I don't think so," Uggla said of a possible snowball effect with the defensive miscues. "You can say the term, 'When it rains it pours.' It's just the way it went tonight. You can't do anything about it.
"Still had a lot of fun. I wouldn't trade it for anything."
Uggla typically plays solid defense, and he had six errors in 80 games this season.
"My reputation is what it is," he said. "One night's not going to change it. It doesn't change how I go about it. If someone else wants to say something about it, let them say it, but I know what kind player I am and I know that my defense is going to be fine after today."
Added NL manager Clint Hurdle: "My heart goes out to the young man. He's such a good player, you know. Such a good player. Obviously, that's not the kind of night you want to have in the All-Star Game. You have that kind of night in the season, you get to play the next day."
Uggla wasn't much better at the plate, either. He was 0-for-4 with three strikeouts and six runners left on base.
After a rough 4-hour, 50-minute game, Uggla was still able to think to the pregame ceremony featuring 49 Hall of Famers.
"I'll tell you what, I was holding back some tears, man," Uggla said. "I had some chills going. That was probably the coolest things I've ever been a part of."
Uggla was also glad he had Marlins teammate Hanley Ramirez there, as the NL's starting shortstop went 2-for-3 with one run in the leadoff spot.
"It was great," Uggla said. "He definitely deserved it. I thought he deserved it last year. To have him here with me, for me to be here with me, it was great. He's a great player and he had a great game tonight."