This year's renewal of the annual event is called the 2008 Taco Bell All-Star Legends and Celebrity Softball Game, and it's part of Taco Bell All-Star Sunday and 2008 Major League Baseball All-Star Week.
The temporary fences will be pulled in at Yankee Stadium and the fun will start at 4 p.m. ET.
Celebrities scheduled to appear include actor and comedian Billy Crystal, who played for the Yankees in a Spring Training game in March, plus Oscar winners Whoopi Goldberg and Marlee Matlin.
"I'm a Chicago girl, and as such, I've always loved watching and playing baseball," Matlin said. "Playing ball is my extracurricular activity while working on a film or TV show, and I bring my mitt with me everywhere I go. Now, to be able to play in the House that Babe Ruth Built is just too wild to believe. I can't wait!"
Also on hand among the stars will be comedians Chris Rock and George Lopez, celebrity chef Bobby Flay, director Spike Lee, defensive end Justin Tuck from the Super Bowl champion New York Giants, actor Jerry Ferrara, who's better known as Turtle on "Entourage," celebrity softball game veteran James Denton of "Desperate Housewives," TV correspondents Maria Menounos and AJ Calloway and actors William Baldwin and Kyle Massey.
Major League Baseball legends scheduled to appear include Hall of Famers Ozzie Smith, Rich "Goose" Gossage, Tony Perez, Dave Winfield, George Brett, Ernie Banks, Gary Carter, Rollie Fingers, Wade Boggs and Paul Molitor plus seven-time All-Star Tim Raines and Yankees legends Tino Martinez and Paul O'Neill.
ESPN anchor Kenny Mayne will be a team manager and Mike Golic and Mike Greenberg of ESPN Radio's "Mike & Mike" show will be the emcees for the game, which will be broadcast by ESPN on Monday, July 14, after the 2008 State Farm Home Run Derby, which begins at 8 p.m. ET.
"The MLB All-Star weekend is easily the highlight of my year," Denton said. "The first year I played third next to Ozzie Smith, and last year I was in an outfield with Fred Lynn and Ricky Henderson. I homered off of Mark 'The Bird' Fidrych. Sure, it was softball, but how do you beat that?"
Added Tuck: "As a kid growing up in Kellyton, Alabama, I was a huge Yankees fan, so I am really excited that Major League Baseball invited me to play in The Taco Bell All-Star Legends & Celebrity Softball Game at Yankee Stadium.
"In addition to winning the Super Bowl this year, this is definitely going to be lots of fun for me. Having teammates like Chris Rock, Billy Crystal, Whoopi Goldberg, George Lopez and Spike Lee is going to be a blast."
Massey, who stars in "Cory in the House," said he was equally thrilled to learn he'd be taking part in the festivities.
"I'm so excited to be playing with all of these amazing celebrities and incredible Hall of Fame baseball players at Yankee Stadium, the most historic place in sports," Massey said.
"I always loved the game of baseball, but it became my favorite sport when the Chicago White Sox gave me a behind-the-scenes tour and I got to watch a game from the perfect perspective of the broadcast booth. I'm so honored for this once-in-a-lifetime and I will be forever thankful to Major League Baseball."
Doug Miller is a Senior Writer for MLB.com/Entertainment. This story was not subject to the approval of Major League Baseball or its clubs.