Overall, Oakland is 14-4-1 -- best in the Cactus League -- while Arizona has played to a 7-11-1 record.
Outfielder Josh Reddick got the A's on the board early in the first against right-hander Josh Collmenter with a three-run homer to right field -- his second this spring -- that scored Collin Cowgill and Eric Sogard, who reached on back-to-back singles.
The red-hot Cowgill hit a triple two innings later, scoring on Sogard's sacrifice fly just minutes before Manny Ramirez launched his second homer of the spring to dead center. Former D-backs prospect Brandon Allen, a favorite for the A's first-base job, joined the long-ball club in the fourth with a solo shot to center field.
A's starter Jarrod Parker, dealt by the D-backs in November, allowed just one hit against his former team in 3 2/3 innings. But he struggled with his command, walking seven and allowing two runs.
Collmenter went three innings for Arizona, allowing five runs on six hits. Gerardo Parra tallied an RBI single in the third inning, and Ryan Roberts collected an RBI in the fourth on a groundout.
The D-backs trimmed the lead to 6-4 in the eighth, when Cody Ransom hit a two-run homer off A's left-hander Jerry Blevins. Paul Goldschmidt made it a one-run game an inning later with a solo shot off righty Justin Souza, who finished it off for his first save of the spring.
Up next for D-backs: The D-backs return to Salt River Fields on Tuesday to take on the Giants. Trevor Bauer, the No. 3 overall pick in last year's Draft will start for the D-backs. He is expected to go four innings while another one of the organization's top prospects, Patrick Corbin, is slated to throw four innings in relief.
Up next for A's: Right-hander Brandon McCarthy is scheduled to make his final Cactus League appearance Tuesday against the visiting Cubs, marking his final tuneup before he takes the mound in Japan for a regular-season matchup with the Mariners on March 28. Behind him, appearing together for the first time in a game this spring, will be center fielder Yoenis Cespedes and left fielder Coco Crisp. First pitch is scheduled for 1:05 p.m. PT at Phoenix Municipal Stadium.