After Endy Chavez led off the bottom of the first with a single and J.J. Hardy followed with a double, Jones' three-run blast to center off Yankees starter Ivan Nova delighted the sold-out crowd of 8,686 -- an Ed Smith Stadium attendance record. Two batters later, Wieters smacked a solo homer to right.
The Yankees received a scare in the top of the sixth inning, when All-Star second baseman Robinson Cano departed after swinging at a Troy Patton pitch that struck him on the left hand. Cano, 29, doubled over in apparent pain and was immediately seen on the field by head athletic trainer Steve Donohue, who helped the slugger into the third-base dugout.
Nova found a groove after Baltimore's four-run first, completing four innings and allowing five runs on seven hits in all, striking out four without walking a batter in his fourth Grapefruit League start.
"The first two innings, he had no rhythm," Yankees manager Joe Girardi said of Nova. "The last two innings, he had great rhythm; he was working quick and looked very good to me. He just couldn't seem to get in a rhythm the first two innings, and then he found it."
Orioles right-hander Alfredo Simon allowed one run on two hits over two innings in his second Grapefruit League start (third appearance). Simon, who is competing to make the O's Opening Day roster as either a starter or reliever, escaped the first inning unscathed before giving up a leadoff double to Mark Teixeira, who eventually scored on a groundout to first by Bill Hall.
The Orioles added a run in the second inning, when Ryan Flaherty hit a leadoff single, advanced to second on a bunt by Robert Andino and came around to score on a single to right by Chavez.
The Yankees pulled to within three runs in the top of the seventh, when a Dewayne Wise double brought home Hall and Jose Gil followed with a sacrifice fly that plated Chris Dickerson.
Baltimore right-hander Mike Wright worked 2 1/3 scoreless innings, striking out four without issuing a walk.
Up next: The Orioles will enjoy a scheduled off-day on Monday, then start Brian Matusz -- who has posted 13 strikeouts against no walks thus far in Grapefruit League play -- against the Phillies on Tuesday at 1:05 p.m. ET in Sarasota, Fla.
Chris Girandola is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.