Joining Cole on the East squad will be Pirates outfield prospect Robbie Grossman, who currently leads the AFL with 32 hits.
The game will be played at 8:10 p.m. ET on Saturday and will be televised by MLB Network and online at MLB.com.
Grossman has been one of the offensive stars in the AFL season so far, hitting .372 with an AFL-best six homers. The former sixth-round pick has driven in 19, scored 15 runs and swiped four bases in 22 games.
After the interruption for the Rising Stars Game, the AFL season will continue through Nov. 17.
Jenifer Langosch is a reporter for MLB.com. Read her blog, By Gosh, It's Langosch, and follow her on Twitter @LangoschMLB. This story was not subject to the approval of Major League Baseball or its clubs.