Greinke is coming off a poor outing against the Rockies in the NL Wild Card Game on Wednesday in which he allowed four runs on six hits and lasted just 3 2/3 innings.
That outing was a rare poor performance at home for Greinke, who was 13-1 with a 2.87 ERA in 18 regular-season starts at Chase Field.
In that game, the D-backs handed Greinke a 6-0 lead after three innings but he was unable to get through the fourth before allowing four runs.
Greinke, who pitched for the Dodgers from 2013-15, is 1-2 with a 3.65 ERA in four starts this season against his former club.
Steve Gilbert has covered the D-backs for MLB.com since 2001. Follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.